Calorie restriction in humans shows benefits

One of the first studies to explore the effects of calorie restriction in humans (reducing caloric intake by 15% for two years) decreases the effects of aging, metabolism, and protection against age-related diseases. The study found that calorie restriction decreased systemic oxidative stress. Which has been linked to age-related neurological conditions. Such as Alzheimer’s and Parkinson’s, as well as with cancer, diabetes and others.

Study

CALERIE (Comprehensive Evaluation of the Long-Term Effects of Energy Reduction) was the first randomized controlled trial to evaluate the metabolic effects of calories in nonobese humans. The second phase of the study looked at the results of 53 healthy, nonobese men and women between the ages of 21 and 50 who reduced calories by 15% over 2 years and underwent additional measures for metabolism and oxidative stress. Calorie reductions were calculated individually through the ratio of isotopes absorbed by molecules and tissues over 2 weeks. A precise identification technique. Participants lost an average of almost 9 kg. Although they did not follow a particular diet and weight loss was not the goal of the study**. No adverse effects** were observed, such as anemia, excessive bone loss or menstrual disorders. In fact, both trials led to improvements in mood and health-related quality of life. “We found that even people who are healthy can receive benefits from a calorie control system.” Says lead author Leanne M. Redman, associate professor of Clinical Sciences at Pennington Biomedical Research in Baton Rouge, LA. Redman emphasized that CALERIE looked at the effects of calories on aging. Without the weight loss. Where discussions about “fast” or “slow” metabolism often arise. “We know from studies in mammals that the smaller the mammal, the faster its metabolism and the shorter its longevity,” he says. Many factors, such as antioxidants and dietary and biological factors, influence metabolism. But current theories that slower metabolism is more beneficial to health and that organisms burn more efficiently should experience greater longevity. Next steps include analysis of adult biomarkers, antioxidant effects and other substances that mimic calorie restriction. Calorie restriction goes beyond just losing weight when we talk about benefits for our patients.